4 edition of Antiepileptic drug therapy in pediatrics found in the catalog.
|Statement||editors, Paolo L. Morselli, C.E. Pippenger, J. Kiffin Penry.|
|Contributions||Morselli, Paolo Lucio., Pippenger, C. E., Penry, J. Kiffin, 1929-, International League against Epilepsy., CIBA-GEIGY Limited.|
|LC Classifications||RJ496.E6 A57 1983|
|The Physical Object|
|Pagination||xii, 369 p. :|
|Number of Pages||369|
|LC Control Number||81048500|
Affiliation:Department of Pediatrics,University of Chieti, Via dei Vestini n. 5, I Chieti, Italy. Keywords:Antiepileptic drugs, adverse, effects- hormonal changes. Abstract: Epilepsy is a neurological disorder commonly seen in pediatric age. A large number of anti epileptic Drugs are now available for the treatment of this disease. The first 8 chapters review general concepts and substantial facts about epilepsy and antiepileptic drugs. The next 22 chapters are devoted to optimal therapy for individual underlying medical conditions or for particular adverse effects. Overall, the structure of the book and the list of chapters have remained unchanged from the first edition.
Triple bromide elixir was used as an adjunctive antiepileptic drug in 11 children whose seizure disorders were intractable to other antiepileptic therapy. The patients' ages ranged from 2 to 17 years. The seizure disorders treated included photosensitive epilepsy (one case), acquired epileptic aphas . Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is widely established for older generation AEDs, whereas there is limited evidence about newer AEDs. Our aim is to assess the benefit of TDM of newer generation AEDs in epilepsy. Methods.
General Principles of Therapy --Treatment Decisions in Childhood Seizures / Shlomo Shinnar and Christine O'Dell --Comparative Anticonvulsant Profile and Proposed Mechanisms of Action of Antiepileptic Drugs / H. Steve White and Karen S. Wilcox --Evidence-Based Medicine Issues Related to Drug Selection / Tracy A. Glauser and Diego A. Morita. After 3 months of lacosamide add-on therapy, % of patients achieved a ≥50% reduction in seizure frequency. 12 Lacosamide efficacy and safety were also evaluated in two series including both children and adults, 16 In particular, a comparison study of lacosamide efficacy and safety in pediatric and adult patients with uncontrolled focal.
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Antiepileptic drug (AED) therapy starts with an accurate diagnosis of epilepsy and is followed by sequential drug trials. Seizure freedom is largely achieved by the first two drug trials; thus, epilepsy that cannot be controlled after appropriately conducted trials of the first two drugs is defined as drug-resistant epilepsy (DRE).Cited by: 6.
Unlike other chronic disease states for which nonpharmacologic therapy may be considered first line, in patients with epilepsy, medication is first-line therapy. Choosing the appropriate medication at the appropriate dose is crucial, as patients are considered to have refractory epilepsy if they fail 2 antiepileptic drugs (AEDs) that are.
Rationale: Oxcarbazepine (OXC) is an antiepileptic drug (AED) approved for monotherapy or adjunctive therapy in the treatment of partial onset seizures in adults and children ages 4–16 years. Current prescribing information on conversion to OXC monotherapy in patients receiving other AEDs recommends gradual titration of OXC with the dose of.
Pediatrics pharmacology: Anticonvulsant Therapy 1. A Haleem ni University Of Duhok College of pharmacy Pediatrics Department [email protected] 2. Definition Seizure (Convulsion): the clinical manifestation of an abnormal and excessive excitation of a population of cortical neurons.
Epilepsy: a disease characterized by. Abstract. Epilepsy affects approximately 1% of the population. First-line treatment for epilepsy is the administration of anti-seizure medication, also referred to as antiepileptic drugs (AEDs), although this nomenclature is erroneous as these medications typically do not impact underlying epileptogenic processes; the goal of these medications is to control : Tesfaye Zelleke, Archana Pasupuleti, Dewi Depositario-Cabacar, Amy Kao.
The extensively updated third edition of Pediatric Epilepsy: Diagnosis and Therapy continues to be the definitive volume on the diagnosis, treatment, classification, and management of the childhood epilepsies.
Written by nearly international leaders in the field, this new edition progresses logically with major sections on the basic mechanisms of the disease, classification, epidemiology. In our prior study, 58% of young children with epilepsy and their families exhibited nonadherence to antiepileptic drugs (AEDs) in the first 6 months of treatment.
1 However, the patterns of nonadherence vary in course and level of nonadherence: mild, moderate, severe early, and severe delayed nonadherence.
1 Although identifying adherence patterns was an important first step to. Modi AC, Rausch JR, Glauser TA. Patterns of nonadherence to antiepileptic drug therapy in children with newly diagnosed epilepsy. JAMA ; Modi AC, Rausch JR, Glauser TA.
Early pediatric antiepileptic drug nonadherence is related to lower long-term seizure freedom. Neurology ; Introduction. Antiepileptic and anticonvulsant agents are among the commonly used drug classes in intensive care units (ICUs).
Antiepileptic drugs (AEDs) are also initiated in ICUs as prophylactic drugs in patients with traumatic brain injury, meningitis, and brain neoplasms. 1 Febrile convulsions is a unique indication in children to receive anticonvulsant drugs in pediatric ICUs.
Antiepileptic Drugs. Sodium Valproate (–1, mg/day) and topiramate (50– mg/day) were evaluated for prophylactic therapy of pediatric migraine in some controlled studies.
In the last 8 years, one RCT compared the efficacy of valproate and propranolol for the preventive treatment of migraine in the pediatric age. Chapter 17 - Antiepileptic Drug Therapy in Neonates. with the unique features of neonatal physiology affecting considerations for many of the antiepileptic drugs (AEDs) commonly used for older children and adults.
High-quality evidence in neonates is lacking for many of these treatments, with use of many drugs based on historical precedent. 1. Introduction.
During the last decade, the two mainstays of epilepsy treatment, epilepsy surgery and antiepileptic drug (AED) therapy, have made great advances, resulting predominantly from advances in imaging techniques and the development of new AEDs.
The use of antiepileptic drugs (AEDs) is the primary modality for the mitigation of symptoms and disease management. AEDs are a diverse group of compounds with a history reaching back to the s. From a historical perspective, potassium bromide was the first compound used therapeutically for recurrent seizures.
This study, conducted by the Medical Research Council [MRC] Antiepileptic Drug Withdrawal Study Group, and was published in [14,Class II]. The primary criterion for inclusion was a seizure-free period of 2 years on AEDs, and patients were randomized to either continued drug treatment or a slow withdrawal over 6 months.
Diego Morita, MD, is an assistant professor of pediatrics and neurology at Cincinnati Children's Hospital Medical Center.
Morita's interests currently include the objective assessment of antiepileptic drug side effects, pharmacogenetics of antiepileptic drugs, and individualization of drug therapy. Proceedings of a symposium on antiepileptic drugs in newborns, infants, children and adolescents held at Hilton Head Island, S.C., Dec.
and sponsored by. Abbreviations: AEDs, antiepileptic drugs; FDA, Food and Drug Administration. Journal of Pediatric Epilepsy Vol. 6 No. 1/ 4 Effects of AEDs on Pediatric Cognition, Mood, and Behavior Afzal et al.
This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited. PURPOSE OF REVIEW This article is an update from the article on antiepileptic drug (AED) therapy published in the last Continuum issue on epilepsy and is intended to cover the vast majority of agents currently available to the neurologist in the management of patients with epilepsy.
Treatment of epilepsy starts with AED monotherapy. Knowledge of the spectrum of efficacy, clinical pharmacology. DRUG INTERACTIONS Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children CorrespondenceProfessor Oscar Della Pasqua, Clinical Pharmacology & Therapeutics Group, University College London, BMA House, Tavistock Square, London WC1H 9JP, UK.
Tel.: +44 ; E-mail: [email protected] Rational management of antiepileptic drug therapy in children requires an understanding of pharmacokinetics, pharmacodynamics, and toxicology of these agents. Pharmacokinetics is the study of drug absorption, distribution, metabolism, and elimination: that is, what the body does to a drug.
Antiepileptic Drug Therapy in Pediatrics by Paolo L. Morselli, C. E. Pippenger and J. Kiffin Penny, Raven Press, $ (xii + pages) ISBN 0 3 There has been a positive explosion over recent years in the number of books appearing on .1. Epilepsia. ;36 Suppl 2:S Antiepileptic drugs in pediatric practice.
Bourgeois BF(1). Author information: (1)Department of Neurology, Washington University School of Medicine, St. Louis, MissouriUSA. Several factors characterize the current medical treatment of .Antiepileptic drug: decreases the frequency and/or severity of seizures in people with epilepsy!
Antiepileptic drug: Treats the symptom of seizures, not the underlying epileptic condition! Goal of therapy: maximize quality of life by minimizing seizures and adverse drug .